10 American Road Trips That You Should Do Once in Your Life

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10 American Road Trips That You Should Do Once in Your Life

There’s nothing quite like an American road trip. The U.S. is so massive and so diverse that driving through one region can feel like a completely different world compared to another. You’ve got the wide open deserts of the Southwest, the lush mountains of the Pacific Northwest, palm-lined coastal highways in California, and then suddenly you’re cruising past cornfields in the Midwest or through Spanish moss-draped roads in the South. It’s wild how different each part of the country feels—and that’s exactly what makes road tripping here so special.

I’ve done quite a few road trips in the U.S. myself—some short, some long, some in freezing snow, others in 100-degree heat. I’ve driven up and down the East Coast, explored the stunning highways along the West Coast, and even spent a full month on the road from Nashville to Hawaii. Yes, that last part obviously involved a flight or two, but you get what I mean. Over the years, I’ve been to more than 15 U.S. states and have seen everything from red rock canyons to misty forests to beaches that actually look like they belong in the Caribbean.

I’ve rented cars across the country (some great, some… questionable), figured out how to save on gas, planned routes around national parks, and yes, even learned the hard way to always check if your Airbnb has parking. So this list comes with real experience behind it, and I genuinely hope it helps if you’re thinking about hitting the road. Whether you’ve got a long weekend or a full summer to explore, these ten US road trips are the kind you’ll be talking about for years.

Important Information When Organizing a Road Trip in the USA

Before you hit the road, there are a few things you’ll want to know that can save you time, money, and frustration. Road tripping in the U.S. is generally straightforward, but there are quirks that can catch you off guard—especially if it’s your first time doing it.

• One-way car rentals can get expensive. Renting a car in one state and dropping it off in another is totally doable, but it often comes with an additional fee. Sometimes that fee is small, but other times it can be hundreds of dollars—especially if you’re going cross-country. It’s worth checking this before booking, or even comparing different pickup/drop-off city combinations to see what saves you the most.
• Most U.S. roads are wide and straight. Driving is usually pretty easy in terms of road design—especially compared to places with narrow, winding streets. That said, it can also get boring fast. You’ll find yourself on long highways with nothing but flat land for miles. Make sure you’ve got music, podcasts, or snacks to help pass the time (and keep you awake if you’re driving solo).
• Distances can be deceiving. A place might look “close” on the map, but in the U.S., it can still mean hours of driving. Tourists often underestimate this and end up stuck with too much drive time and not enough wiggle room. Always check your route and driving time, and try to leave early—especially if you’re trying to visit multiple places in one day.
• Time zones matter more than you’d think. In places like the border of Utah and Arizona, the time zone shifts suddenly. This is especially important if you’re visiting Antelope Canyon (Lower or Upper), where guided tour times are strictly scheduled. Make sure your phone or GPS updates correctly, or you might show up an hour late without realizing it.
• National Parks need planning. If your trip includes national parks, don’t just wing it. Some are massive—driving from one end to the other can take hours. Summer temperatures can also be brutal, especially in places like Death Valley or Zion. Always bring extra water, snacks, and a planned route. And please, don’t start a random hike at 4pm. You won’t want to be out there when the sun drops and the trails are empty.
• Watch out for carpool lanes on highways. In many U.S. states—especially California and parts of the East Coast—you’ll see special lanes on the left side of the highway marked for “HOV” or “Carpool” use. These lanes are reserved for vehicles with at least 2 or sometimes even 3 people during certain hours. If you’re driving solo and accidentally use one, you can get a hefty fine.

How to Plan a Road Trip in the USA

If you want your road trip to be fun and not stressful, a bit of planning goes a long way. Here’s how I usually approach it:

• Figure out what you actually want to see. Are you into big cities, quiet small towns, beach views, national parks, or mountain hikes? Your interests will help guide which region of the U.S. makes the most sense. For example, if you’re dreaming of canyons, red rocks, and epic desert views, Utah and Arizona are perfect. You won’t find that same vibe in California or the East Coast.
• Decide on your budget and timeline. A road trip that lasts two weeks is not the same as one that lasts two months. Same goes for how much you can spend. A $500-a-week trip will look very different from a $5,000-a-week one. Knowing your time and money limits will help you narrow things down right away.
• Accept that you won’t see it all. The U.S. is huge—like, really huge. You can’t see everything in one go, and that’s okay. Focus on a manageable area instead of spreading yourself too thin and spending all your time in the car.
• Grab a map and pinpoint the spots you’re most excited about. Once you’ve got your wishlist, check the actual distances—not just in kilometers or miles, but in hours. Decide how far you’re comfortable driving in one go. Some people are fine with 6-hour drives, others prefer 2-hour hops with stops along the way.
• Use all of that to sketch a rough itinerary. Once you know where you’re going, how much time you have, and how long you want to drive each day, you can start mapping out a route. Don’t stress about it being perfect—just get a rough draft going, and you can always tweak it as you go.

1. Pacific Coast Highway, California

If you’re after jaw-dropping coastal views, charming beach towns, and a mix of nature and culture, the Pacific Coast Highway (also called Highway 1) is one of the most iconic road trips you can take in the U.S. It’s especially perfect for couples, solo travelers, or friends who want a mix of beach time, sightseeing, and foodie stops. This road trip feels relaxing but still full of things to see and do—so it’s ideal if you want a scenic drive without having to hike through the desert or climb any mountains.

You can technically drive the whole route in one or two days, but to actually enjoy it, I recommend giving yourself 5 to 7 days. That way, you’ll have time to stop in the towns along the way and not feel rushed.

Here are some of the best places to stop on this road trip:

• San Francisco: Start your trip with some city exploring—Golden Gate Bridge, cable cars, and sourdough bread. Check out our guides on how to spend 3 days in San Francisco, mistakes to avoid in the city and activities you shouldn’t miss in San Francisco.
• Half Moon Bay: A great first stop if you want cliffside views and coastal trails.
• Santa Cruz: A fun surf town with a vintage boardwalk vibe.
• Big Sur: This stretch is why people do this drive. It’s wild, dramatic, and feels untouched. Pull over often.
• Carmel-by-the-Sea: Adorable town with cute shops, white sand beaches, and a relaxed vibe.
• San Luis Obispo: A good overnight stop with local wine tasting and cool hikes.
• Santa Barbara: A mix of beach, upscale boutiques, and Mediterranean architecture. Check out the best sunset cruises in Santa Barbara to really enjoy this stunning town.
• Malibu and LA: Wrap up with classic Southern California views, palm trees, and city buzz.

This one’s less about the destination and more about the in-between moments. It’s a vibe from start to finish.

2. Route 66

Route 66 is the classic American road trip. If you want a mix of kitschy roadside attractions, ghost towns, quirky diners, and real Americana vibes, this one’s for you. It’s ideal for travelers who love a nostalgic feel, enjoy taking the scenic route, and don’t mind a bit of adventure. Whether you’re going solo, as a couple, or with friends, Route 66 offers a bit of everything—from deserts and motels to vintage signs and wide-open skies.

The original Route 66 stretches from Chicago, Illinois to Santa Monica, California, covering over 2,400 miles. To enjoy it fully without rushing, I’d recommend giving yourself at least 2 to 3 weeks. If you’re short on time, you can always do a shorter stretch—like Chicago to Oklahoma, or Albuquerque to Flagstaff—but the full route really gives you the full picture.

Some of the best spots along the way include:

• Chicago, IL: Start your journey in the Windy City with deep-dish pizza and skyline views.
• St. Louis, MO: Check out the Gateway Arch and classic diners.
• Tulsa & Oklahoma City, OK: Lots of Route 66 history, plus murals and museums.
• Amarillo, TX: Don’t skip Cadillac Ranch—bring a can of spray paint!
• Santa Fe, NM: A detour from the original route but well worth it for the art, food, and adobe architecture.
• Albuquerque, NM: Great stop for Route 66 neon signs and Southwestern style.
• Flagstaff, AZ & the Grand Canyon: You’re close enough here that it’s worth the side trip.
• Kingman, AZ: One of the most authentic Route 66 towns still going strong.
• Santa Monica, CA: End your trip at the Pacific Ocean—walk the pier and take it all in.

Check out these mistakes to avoid in Santa Monica here.

I also recommend checking out these gorgeous cabins to rent in Oklahoma.

3. Blue Ridge Parkway

If you’re looking for peaceful drives, mountain views, and cozy towns, the Blue Ridge Parkway might just be your perfect road trip. It runs through the Appalachian Mountains, connecting Shenandoah National Park in Virginia to Great Smoky Mountains National Park in North Carolina, and it’s especially stunning in the fall when the leaves turn every shade of orange, red, and gold. This route is ideal for people who love nature, photography, slower travel, and charming small towns with local character.

The full parkway is about 470 miles long, and while you could technically drive it in a couple of days, I’d suggest planning 5 to 7 days if you want to make the most of it. It’s not a fast road—there are no billboards, no big gas stations, and the speed limit is usually around 45 mph—but that’s the whole point. It’s a drive to slow down and enjoy.

Some of the top stops along the way:

• Shenandoah National Park (VA): Start your trip with Skyline Drive, which connects directly to the parkway.
• Mabry Mill (VA): One of the most photographed spots on the route and a great stop for pancakes.
• Blue Ridge Music Center (VA): Learn about Appalachian music and maybe catch a live performance.
• Blowing Rock (NC): A cute town with boutique shopping and mountain views.
• Linville Falls (NC): A short hike to a beautiful waterfall—easy and worth it.
• Craggy Gardens (NC): Perfect for sunrise or sunset views.
• Asheville (NC): End your trip with good food, breweries, and a visit to the Biltmore Estate.

This is a road trip for people who love winding roads, fresh air, and the kind of places where time feels slower—in the best way.

4. Great River Road

The Great River Road follows the Mississippi River from northern Minnesota all the way down to Louisiana, stretching across ten states. If you want a road trip that’s rich in history, full of cultural variety, and packed with river views and small-town charm, this one is a hidden gem. It’s perfect for travelers who like slower-paced routes, historical landmarks, and local food—especially if you’re into Southern cooking and Midwest hospitality.

You’ll be covering over 2,000 miles, so I’d recommend giving yourself at least 2 to 3 weeks if you want to experience more than just the drive. You could also choose a shorter section—like Minnesota to Iowa, or Memphis to New Orleans—depending on how much time you have.

Some of the best stops along the Great River Road:

• Itasca State Park (MN): Where the Mississippi River begins. You can actually walk across it here.
• Minneapolis & St. Paul (MN): A mix of city energy and riverfront parks.
• Dubuque (IA): A charming Mississippi River town with historic buildings and a great view from the Fenelon Place Elevator.
• St. Louis (MO): Home of the Gateway Arch and a major river hub with tons of history.
• Memphis (TN): BBQ, blues, and Elvis. Don’t skip Beale Street or the Civil Rights Museum.
• Vicksburg (MS): A historic Civil War city with scenic river views and battlefields to explore.
• Baton Rouge (LA): Good food, good people, and a mix of old and new Southern culture.
• New Orleans (LA): A perfect ending with jazz, beignets, and colorful streets you’ll never forget. Here are mistakes to avoid in New Orleans.

This route isn’t just about the destination—it’s about the changing pace of life as you follow one of the most iconic rivers in the world.

5. The Overseas Highway, Florida Keys

If you want a short but unforgettable road trip packed with sunshine, clear blue water, and tropical vibes, the Overseas Highway is the one. This route connects Miami to Key West, running across a string of islands through the Florida Keys—and yes, you’re literally driving over the ocean for parts of it. It’s perfect for couples, solo travelers, or families looking for a warm-weather getaway with laid-back stops and some of the prettiest ocean views in the U.S.

The drive itself is only about 110 miles, so you can technically do it in a day. But to actually enjoy it, I recommend giving yourself 3 to 5 days. That way, you can slow down, swim, snorkel, and check out the towns along the way without rushing.

Top spots to check out along the way:

• Key Largo: The first stop in the Keys and a great place for snorkeling or diving in John Pennekamp Coral Reef State Park.
• Islamorada: Known for sport fishing, fresh seafood, and some of the best sunset spots.
• Marathon: A solid halfway point with turtle rescues, kayak rentals, and quieter beaches.
• Seven Mile Bridge: One of the most famous parts of the drive—don’t forget to stop and take a photo.
• Bahia Honda State Park: White sandy beaches and crystal clear water, perfect for a swim or a picnic.
• Key West: The final stop with a mix of history, beach bars, pastel houses, and the southernmost point of the continental U.S.

This road trip is all about the island pace—no stress, no rush. Just good food, good views, and the kind of weather that makes you want to wear flip-flops every day.

6. Going-to-the-Sun Road, Glacier National Park

Going-to-the-Sun Road isn’t just a road trip—it’s an experience. Winding through Glacier National Park in Montana, this route takes you straight through alpine forests, past glacial lakes, and along cliffs that make your jaw drop (and maybe your palms sweat a little). It’s perfect for travelers who love nature, scenic drives, and mountain air. If you’re someone who prefers the wild outdoors over city life, this is your kind of trip.

The full drive is only 50 miles, but don’t let the short distance fool you. With all the pull-offs, hiking trails, and wildlife sightings, you’ll want to give yourself 2 to 4 days to really enjoy the area—especially since weather and traffic can affect your plans. Also keep in mind: this road is only open seasonally, usually from late June to mid-October, depending on snow conditions.

Here are some key stops and highlights:

• Lake McDonald: A huge glacier-carved lake with colorful pebbles and kayak rentals.
• Trail of the Cedars: A short, accessible loop trail that takes you through an ancient forest.
• Logan Pass: The highest point on the road with access to popular hikes like Hidden Lake and Highline Trail.
• Jackson Glacier Overlook: One of the best chances to actually spot a glacier from the road.
• St. Mary Lake: Gorgeous views, especially early in the morning when the water is still and reflective.

You’ll need to reserve a vehicle entry ticket during peak summer months, and cell service is basically nonexistent—so plan ahead, bring water and snacks, and download maps offline. This drive is unforgettable and absolutely worth it, especially if you want to feel like you’re in the middle of nowhere in the best possible way.

Here are mistakes to avoid in Glacier National Park.

7. The Loneliest Road (U.S. Route 50), Nevada

If you want wide open space, dramatic desert views, and that feeling of being truly off the grid, U.S. Route 50 through Nevada—also known as The Loneliest Road in America—is the road trip to take. This one is for travelers who enjoy solitude, empty highways, and small towns that still feel stuck in time. It’s not flashy, but it’s definitely unforgettable. If you’ve ever wanted to drive for miles without seeing another car, you’ll love this.

The Nevada stretch of Route 50 runs from Ely to Carson City, covering about 400 miles. You could drive it in a day, but I recommend giving yourself 2 to 4 days so you can explore the quirky stops along the way. There’s something about this route that feels peaceful, a little eerie, and very cinematic.

Here are some must-see stops along the way:

• Ely: A historic mining town and great starting point. Check out the Nevada Northern Railway Museum.
• Great Basin National Park: One of the least-visited national parks but totally worth it—especially for stargazing and the Lehman Caves.
• Eureka: A small town with old-school Western architecture and a surprisingly pretty courthouse.
• Austin: Tiny and rugged, with old mining history and nearby hot springs.
• Sand Mountain: A massive white sand dune in the middle of the desert—perfect for photos or climbing if you’re up for a challenge.
• Fallon: Your first real sign of modern civilization before reaching Carson City.

This road isn’t packed with attractions, and that’s the point. It’s about slowing down, embracing the quiet, and seeing a side of America most people skip. Bring extra water, fill up on gas when you can, and enjoy the silence—you won’t get cell service for most of it.

8. Route 1, Maine

If you’re looking for a coastal road trip with lighthouses, lobster rolls, and charming little towns, Route 1 in Maine delivers all that and more. It runs along the eastern edge of the state, following the Atlantic coast and winding through fishing villages, forests, and scenic viewpoints. It’s a great pick for couples, families, or solo travelers who want a slower-paced trip full of good food and pretty views.

And yes—it’s especially gorgeous in the fall. From late September through October, the trees light up with red, orange, and golden leaves, and when you pair that with crisp air and quiet coastal roads, it feels like something out of a New England movie. It’s a much more relaxed alternative to the busier inland foliage routes, but you still get all the fall color.

Route 1 covers a lot of ground, but the most scenic stretch runs from Portland to Lubec, near the Canadian border. You’ll want at least 5 to 7 days to explore this properly, especially if you’re stopping for hikes, seafood, and photo ops.

Top places to stop along Route 1:

• Portland: A foodie hub with cobblestone streets, cute shops, and great craft beer.
• Freeport: Home of L.L. Bean and lots of outlet stores if you’re into shopping.
• Camden: A postcard-perfect coastal town with harbor views and nearby hikes like Mount Battie.
• Rockland: Art galleries, lighthouses, and the famous Maine Lobster Festival in summer.
• Bar Harbor & Acadia National Park: A little detour off Route 1 but absolutely worth it for coastal hikes and fall foliage.
• Lubec: The easternmost point in the U.S., with dramatic cliffs and wild ocean views.

This road trip is all about slow mornings, cozy towns, and stopping for pie whenever you see a roadside sign.

Here are mistakes to avoid when traveling to Maine.

9. Natchez Trace Parkway

The Natchez Trace Parkway is a peaceful and scenic drive that stretches from Natchez, Mississippi to Nashville, Tennessee, passing through Alabama along the way. It’s perfect if you’re looking for a quiet road trip filled with natural beauty, historical landmarks, and small-town charm. The entire parkway is managed by the National Park Service, which means no billboards, no gas stations directly on the road, and no heavy traffic—just trees, rivers, trails, and tons of history.

This road trip is ideal for couples, retirees, or anyone who wants to unplug and enjoy the ride without rushing. If you’re not into city crowds and you prefer a slower, nature-heavy road trip, this is for you. I recommend 4 to 6 days to enjoy it properly, though you could easily stretch it into a full week if you like to hike or explore small towns.

Here are some of the best stops along the Natchez Trace Parkway:

• Natchez, MS: Start in this charming Southern town with historic homes, views of the Mississippi River, and lots of local flavor.
• Mount Locust Inn & Plantation: One of the oldest structures on the Trace, with a simple look into 1800s travel.
• Emerald Mound: A prehistoric Native American site just off the road—quiet and fascinating.
• Tupelo, MS: Elvis Presley’s birthplace! Stop by the small museum and take a break in this friendly town.
• Cypress Swamp (MS): A beautiful short walk through a mossy, mysterious swamp full of cypress trees.
• Pharr Mounds: A collection of Native American burial mounds along the parkway.
• Leiper’s Fork, TN: Just outside Nashville, this artsy little village is great for food, antiques, and a dose of small-town Tennessee.

This route isn’t about big sights—it’s about the peaceful in-between. Expect slow drives, bird sounds, and the kind of quiet that’s hard to find these days.

10. Million Dollar Highway, Colorado

If you’re up for dramatic mountain views, steep cliffs, and winding roads that’ll have your heart racing a little (in a good way), the Million Dollar Highway in Colorado is a must. It runs for about 25 miles between Silverton and Ouray, but don’t let the short distance fool you—this stretch of U.S. Route 550 packs in more scenery than some entire road trips. It’s ideal for adventurous travelers, couples, or anyone who loves jaw-dropping views, small mountain towns, and a bit of adrenaline behind the wheel.

I recommend planning 2 to 3 days for this area so you can explore the nearby towns, take photos, and enjoy the hikes and hot springs along the way. If you’re combining it with a bigger Colorado or Southwest road trip, this section makes for a great highlight.

Here’s what makes the Million Dollar Highway worth the drive:

• Durango: A fun starting point if you’re coming from the south. It’s got a historic downtown, breweries, and the famous Durango & Silverton Narrow Gauge Railroad.
• Silverton: A tiny, former mining town surrounded by mountains. Great for a lunch stop or a quick look at local history.
• Red Mountain Pass: The highest point on the drive with seriously stunning alpine views. No guardrails here, so drive carefully.
• Ouray: Known as the “Switzerland of America,” this charming town is surrounded by peaks and has relaxing hot springs.
• Box Cañon Falls (Ouray): A powerful waterfall tucked into a narrow canyon—a short walk and totally worth it.

Fall is an amazing time to do this road trip, with golden aspens lighting up the mountains. Just know the road can be intense with sharp turns and drop-offs—so it’s not the best choice for nervous drivers, but if you’re confident behind the wheel, it’s unforgettable.

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